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PK68 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 90 nM). It is selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM. PK68 inhibits necroptosis induced by TNF-alpha, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM). It reduces the number of lung metastases in a B16/F10 murine melanoma model when administered at a dose of 5 mg/kg. PK68 (1 mg/kg) increases survival and prevents decreases in body temperature and increases in serum Il-1beta levels in a mouse model of Tnf-alpha-induced systemic inflammatory response syndrome (SIRS).Formal Name: N-[5-[2-(acetylamino)-6-benzothiazolyl]-2-methyl-3-pyridinyl]-carbamic acid, cyclohexyl ester. CAS Number: 2173556-69-7. Molecular Formula: C22H24N4O3S. Formula Weight: 424.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Soluble, Methanol: Slightly soluble. SMILES: O=C(NC1=CC(C2=CC=C3N=C(NC(C)=O)SC3=C2)=CN=C1C)OC4CCCCC4. InChi Code: InChI=1S/C22H24N4O3S/c1-13-19(26-22(28)29-17-6-4-3-5-7-17)10-16(12-23-13)15-8-9-18-20(11-15)30-21(25-18)24-14(2)27/h8-12,17H,3-7H2,1-2H3,(H,26,28)(H,24,25,27). InChi Key: DRCNWQYEKZTTEW-UHFFFAOYSA-N.
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