Pioglitazone-d4

Pioglitazone-d4 is intended for use as an internal standard for the quantification of pioglitazone (Cay-71745, Cay-10028, Cay-22263) by GC- or LC-MS. Pioglitazone is an agonist of the peroxisome proliferator-activated receptor gamma (PPARgamma, EC50 = ~500-600 nM for both human and murine PPARgamma). It is selective for PPARgamma over PPARalpha, exhibiting low level activation of PPARalpha at 1 µM and 5.4-fold activation at a concentration of 10 µM. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 µM. In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model. Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARgamma antagonist GW 9662 (Cay-70785).Formal Name: 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl-2,3,5,6-d4]methyl]-2,4-thiazolidinedione. CAS Number: 1134163-29-3. Molecular Formula: C19H16D4N2O3S. Formula Weight: 360.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 2.5 mg/ml, DMSO: 2.5 mg/ml. SMILES: CCC1=CN=C(CCOC2=C([2H])C([2H])=C(CC3SC(NC3=O)=O)C([2H])=C2[2H])C=C1. InChi Code: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)/i4D,5D,7D,8D. InChi Key: HYAFETHFCAUJAY-YBNXMSKUSA-N.