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PIN1 inhibitor API-1

TargetMol
PIN1 inhibitor API-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
TGM-T16538-1mg 1 mg

7 - 10 business days*

55.00€
TGM-T16538-5mg 5 mg

7 - 10 business days*

128.00€
TGM-T16538-1mL 1 ml

7 - 10 business days*

142.00€
TGM-T16538-10mg 10 mg

7 - 10 business days*

245.00€
TGM-T16538-25mg 25 mg

7 - 10 business days*

361.00€
TGM-T16538-50mg 50 mg

7 - 10 business days*

538.00€
TGM-T16538-100mg 100 mg

7 - 10 business days*

679.00€
TGM-T16538-200mg 200 mg

7 - 10 business days*

944.00€
TGM-T16538-500mg 500 mg

7 - 10 business days*

1,381.00€
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
 
Description Product Citations Certificate of Analysis Reviews 0
Description
Description: PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the... more
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Product information "PIN1 inhibitor API-1"
Description: PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity. Target: Others. Smiles: Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1. References: Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug,68(2):547-560.
Supplier: TargetMol
Supplier-Nr: T16538

Properties

Application: PIN1 inhibitor
MW: 366.3 D
Formula: C15H13F3N6O2

Database Information

CAS : 680622-70-2| Matching products
KEGG ID : K09578 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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