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Product information "(+)-Pilocarpine (hydrochloride)"
(+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 µM, respectively). It induces salivary secretion in rats when administered intraperitoneally at a dose of 1 mg/kg. Topical administration of (+)-pilocarpine inhibits methylcellulose-induced increases in intraocular pressure in rabbits in a dose-dependent manner. (+)-Pilocarpine is a chemoconvulsant that has been used in the generation of temporal lobe epilepsy animal models. Formulations containing (+)-pilocarpine have been used in the treatment of elevated intraocular pressure and dry mouth.Formal Name: (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride. CAS Number: 54-71-7. Synonyms: NSC 5746. Molecular Formula: C11H16N2O2 . HCl. Formula Weight: 244.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 215 nm. SMILES: CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O.Cl. InChi Code: InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2,/h5,7-8,10H,3-4,6H2,1-2H3,1H/t8-,10-,/m0./s1. InChi Key: RNAICSBVACLLGM-GNAZCLTHSA-N.
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