PIK-III

PIK-III is an inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) that binds a unique hydrophobic pocket (IC50 = 18 nM). It is selective for Vps34 over related PI3K isoforms, PI4Kbeta, and mTOR. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates.Formal Name: 4'-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5'-bipyrimidine]-2,2'-diamine. CAS Number: 1383716-40-2. Synonyms: Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2. Molecular Formula: C17H17N7. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 0.14 mg/ml, PBS (pH 7.2): slightly. lambdamax: 284 nm. SMILES: NC(N=C1)=NC(CC2CC2)=C1C3=CC=NC(NC4=CC=NC=C4)=N3. InChi Code: InChI=1S/C17H17N7/c18-16-21-10-13(15(23-16)9-11-1-2-11)14-5-8-20-17(24-14)22-12-3-6-19-7-4-12/h3-8,10-11H,1-2,9H2,(H2,18,21,23)(H,19,20,22,24). InChi Key: XXSDLQLNIVFIJI-UHFFFAOYSA-N.