PHTPP

PHTPP is a pyrazolo[1,5-alpha]pyrimidine-based ligand that acts as a full antagonist of estrogen ERbeta receptors with 36-fold selectivity over ERalpha. It exhibits no significant agonism on ERalpha or ERbeta. This compound has been used to selectively target ERbeta in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.Formal Name: 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-phenol. CAS Number: 805239-56-9. Molecular Formula: C20H11F6N3O. Formula Weight: 423.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 30 mg/ml. SMILES: OC(C=C1)=CC=C1C(C(C2=CC=CC=C2)=N3)=C4N3C(C(F)(F)F)=CC(C(F)(F)F)=N4. InChi Code: InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H. InChi Key: AEZPAUSGTAHLOQ-UHFFFAOYSA-N.