Phellopterin

Description: Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 µM. Phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. Target: GABA Receptor. Smiles: COc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12. References: Zhao A H, et al. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells[J]. Journal of Asian Natural Products Research, 2012, 14(10):956-965.