PF-9366

PF-9366 is an inhibitor of methionine adenosyltransferase 2A (Mat2A, IC50 = 420 nM for S-adenosyl-L-methionine (SAM) production in an enzyme assay). It is selective for Mat2A over a panel of neurotransmitter transporters, phosphodiesterases, ion channels, and G protein-coupled receptors, as well as a panel of 39 kinases at 10 µM. PF-9366 inhibits SAM production in H520 lung carcinoma cells (IC50 = 1.2 µM) and Huh7 hepatocellular carcinoma cells (IC50 = 225 nM).Formal Name: 7-chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine. CAS Number: 72882-78-1. Molecular Formula: C20H19ClN4. Formula Weight: 350.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.5 mg/ml, Ethanol: 2 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 233 nm. SMILES: ClC1=CC=C2C(C(C3=CC=CC=C3)=CC4=NN=C(CCN(C)C)N42)=C1. InChi Code: InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3. InChi Key: LYLASWLQCMKZAT-UHFFFAOYSA-N.