PF-6274484

PF-6274484 is an inhibitor of the EGF receptor (EGFR, IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).Formal Name: N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide. CAS Number: 1035638-91-5. Molecular Formula: C18H14ClFN4O2. Formula Weight: 372.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml. lambdamax: 253, 342 nm. SMILES: FC1=C(Cl)C=C(NC2=NC=NC3=C2C=C(NC(C=C)=O)C(OC)=C3)C=C1. InChi Code: InChI=1S/C18H14ClFN4O2/c1-3-17(25)24-15-7-11-14(8-16(15)26-2)21-9-22-18(11)23-10-4-5-13(20)12(19)6-10/h3-9H,1H2,2H3,(H,24,25)(H,21,22,23). InChi Key: TUYDDIWQXWTNSW-UHFFFAOYSA-N.