PF-1355

PF-1355 is an irreversible myeloperoxidase (MPO) inhibitor (Ki = 346.74 nM in a cell-free assay). It is selective for MPO over thyroid peroxidase (TPO) and over a panel of more than 50 enzymes, receptors, transporters, and ion channels. It inhibits MPO activity in isolated human whole blood with an IC50 value of 1.5 µM. PF-1355 reduces MPO activity in plasma and peritoneal lavage fluid in a mouse model of peritonitis. It also reduces lung edema, decreases plasma levels of TNF-alpha, MCP-1/CCL2, MIP-2/CXCL2, and KC/CXCL1 and transiently increases and then reduces neutrophil levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary immune complex vasculitis when administered at doses of 20 and 100 mg/kg.Formal Name: 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide. CAS Number: 1435467-38-1. Synonyms: PF-06281355. Molecular Formula: C14H15N3O4S. Formula Weight: 321.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:1): 0.5mg/mL, DMSO: 10mg/mL, Ethanol: 5mg/mL. lambdamax: 221, 275 nm. SMILES: COC1=CC(C(N(CC(N)=O)C(N2)=S)=CC2=O)=C(OC)C=C1. InChi Code: InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22). InChi Key: LJBUZOGABRDGBR-UHFFFAOYSA-N.