PF-07220060

PF-07220060 is an inhibitor of cyclin-dependent kinase 4 (Cdk4, Ki = 0.6 nM for Cdk4/cyclin D1). It is selective for Cdk4 over Cdk6 (Ki = 13.9 nM for Cdk6/cyclin D3). PF-07220060 in combination with fulvestrant (Cay-10011269) increases senescence in HR+HER2- breast cancer cells in vitro but does not induce cell death.Formal Name: 1,5-anhydro-3-[[5-chloro-4-[4-fluoro-2-(1-hydroxy-1-methylethyl)-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2,3-dideoxy-D-threo-pentitol. CAS Number: 2380321-51-5. Synonyms: Atirmociclib. Molecular Formula: C22H27ClFN5O3. Formula Weight: 463.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: O[C@H](COCC1)[C@@H]1NC(N=C2C(C=C3N4C(C)C)=CC(F)=C3N=C4C(C)(C)O)=NC=C2Cl. InChi Code: InChI=1S/C22H27ClFN5O3/c1-11(2)29-16-8-12(7-14(24)19(16)27-20(29)22(3,4)31)18-13(23)9-25-21(28-18)26-15-5-6-32-10-17(15)30/h7-9,11,15,17,30-31H,5-6,10H2,1-4H3,(H,25,26,28)/t15-,17-/m1/s1. InChi Key: QYJLBHRAPDJOSO-NVXWUHKLSA-N.