PF-07104091

PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2, Ki = 1.16 nM). It is selective for Cdk2 over glycogen synthase kinase 3beta (GSK3beta, Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively). In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.Formal Name: carbamic acid N-(1-methylethyl)-(1R,3S)-3-[5-[[[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]amino]-1H-pyrazol-3-yl]cyclopentyl ester. CAS Number: 2460249-19-6. Synonyms: Tagtociclib. Molecular Formula: C19H28N6O4. Formula Weight: 404.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1=CC(COC)=NN1C)NC2=CC([C@@H](CC3)C[C@@H]3OC(NC(C)C)=O)=NN2. InChi Code: InChI=1S/C19H28N6O4/c1-11(2)20-19(27)29-14-6-5-12(7-14)15-9-17(23-22-15)21-18(26)16-8-13(10-28-4)24-25(16)3/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,20,27)(H2,21,22,23,26)/t12-,14+/m0/s1. InChi Key: MTNBRBDFNSGQKB-GXTWGEPZSA-N.