PF-06821497

Item number	Size	Delivery time	Price
TGM-T12430-1mg	1 mg	7 - 10 business days*	97.00€
TGM-T12430-1mL	1 ml	7 - 10 business days*	219.00€
TGM-T12430-5mg	5 mg	7 - 10 business days*	237.00€
TGM-T12430-10mg	10 mg	7 - 10 business days*	371.00€
TGM-T12430-25mg	25 mg	7 - 10 business days*	560.00€
TGM-T12430-50mg	50 mg	7 - 10 business days*	785.00€
TGM-T12430-100mg	100 mg	7 - 10 business days*	986.00€

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Description: PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth... more

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Product information "PF-06821497"

Description: PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition. Target: Histone Methyltransferase. Smiles: ClC1=C2C(=C(Cl)C=C1[C@H](OC)C3COC3)CCN(CC4=C(OC)C=C(C)NC4=O)C2=O. References: Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8,61(3):650-665.

Supplier:	TargetMol
Supplier-Nr:	T12430

Properties

Application:	Targets [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] (EZH2)
MW:	467.34 D
Formula:	C22H24Cl2N2O5
Format:	32160405

Database Information

CAS :	1844849-10-0\| Matching products
KEGG ID :	K11430 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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