PF-04995274

Item number	Size	Delivery time	Price
TGM-T16481-1mg	1 mg	7 - 10 business days*	31.00€
TGM-T16481-1mL	1 ml	7 - 10 business days*	67.00€
TGM-T16481-5mg	5 mg	7 - 10 business days*	67.00€
TGM-T16481-10mg	10 mg	7 - 10 business days*	125.00€
TGM-T16481-25mg	25 mg	7 - 10 business days*	206.00€
TGM-T16481-50mg	50 mg	7 - 10 business days*	367.00€
TGM-T16481-100mg	100 mg	7 - 10 business days*	529.00€

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Description: PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor... more

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Product information "PF-04995274"

Description: PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM). It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S). Target: 5-HT Receptor. Smiles: OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1. References: Chen BK, et al. Prophylactic efficacy of 5-HT4R agonists against stress. Neuropsychopharmacology. 2019 Oct 10.

Supplier:	TargetMol
Supplier-Nr:	T16481

Properties

Application:	5-HT4A / 5-HT4B / 5-HT4D / 5-HT4E partial agonist
MW:	432.51 D
Formula:	C23H32N2O6

Database Information

CAS :	1331782-27-4\| Matching products
KEGG ID :	K04160 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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