PF-04981517

PF-04981517 is a potent, time-dependent inhibitor of the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 30 nM). It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 µM, respectively). PF-04981517 will be useful for understanding the relative roles of CYP3A4 and CYP3A5 in drug metabolism.Formal Name: 1-methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-(1-piperidinyl)-1-pyrrolidinyl]-1H-pyrazolo[3,4-d]pyrimidine. CAS Number: 1390637-82-7. Synonyms: CYP3cide. Molecular Formula: C26H32N8. Formula Weight: 456.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml. lambdamax: 203, 295 nm. SMILES: CC1=CC=C(C2=C(C3=NN(C)C4=C3C(N5C[C@@H](N6CCCCC6)CC5)=NC=N4)C=NN2C)C=C1. InChi Code: InChI=1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1. InChi Key: WDWIMDKOXZZYHH-FQEVSTJZSA-N.