PF-04449913

PF-04449913 is an orally available Hedgehog pathway inhibitor that acts by binding Smoothened (Smo) and blocking signal transduction (IC50 = 5 nM). It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.Formal Name: N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-urea. CAS Number: 1095173-27-5. Synonyms: Glasdegib. Molecular Formula: C21H22N6O. Formula Weight: 374.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.125 mg/ml, Ethanol: 1 mg/ml. lambdamax: 275, 281 nm. SMILES: O=C(N[C@@H]1CCN(C)[C@@H](C2=NC(C=CC=C3)=C3N2)C1)NC4=CC=C(C#N)C=C4. InChi Code: InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1. InChi Key: SFNSLLSYNZWZQG-VQIMIIECSA-N.