PF-00835231

PF-00835231 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro, Kis = 4 and 0.27 nM, respectively). It reduces the infectivity of SARS-CoV and common cold human coronavirus 229E (HCoV-229E) in Vero cells (EC50s = 4.8 and 0.09 µM, respectively).Formal Name: N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-indole-2-carboxamide. CAS Number: 870153-29-0. Molecular Formula: C24H32N4O6. Formula Weight: 472.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 236, 292 nm. SMILES: OCC([C@H](C[C@H]1C(NCC1)=O)NC([C@H](CC(C)C)NC(C2=CC3=C(OC)C=CC=C3N2)=O)=O)=O. InChi Code: InChI=1S/C24H32N4O6/c1-13(2)9-18(23(32)27-17(20(30)12-29)10-14-7-8-25-22(14)31)28-24(33)19-11-15-16(26-19)5-4-6-21(15)34-3/h4-6,11,13-14,17-18,26,29H,7-10,12H2,1-3H3,(H,25,31)(H,27,32)(H,28,33)/t14-,17-,18-/m0/s1. InChi Key: QDIMHKWNHMVDJB-WBAXXEDZSA-N.