Perphenazine-d4

Perphenazine-d4 is intended for use as an internal standard for the quantification of perphenazine (Cay-20735) by GC- or LC-MS. Perphenazine is a typical antipsychotic. It binds to dopamine D2, alpha1A-, alpha2A-, alpha2B-, and alpha2C-adrenergic, M3 muscarinic, and histamine H1 receptors (Kis = 1.4, 10, 1,848, 104.9, 85.2, 810.5 and 8 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 421, 5.6, 132, 17, and 23 nM, respectively). Perphenazine (1, 5, and 10 mg/kg) enhances morphine-induced analgesia in the tail-flick and hot plate tests in rats. It reduces cannibalism in female mice when administered at doses of 2 and 4 mg/kg. Formulations containing perphenazine have been used in the treatment of schizophrenia and psychosis.Formal Name: 4-[3-(2-chloro-10H-phenothiazin-10-yl-1,3,7,9-d4)propyl]-1-piperazineethanol. CAS Number: 155593-75-2. Molecular Formula: C21H22ClD4N3OS. Formula Weight: 408.0. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: OCCN(CC1)CCN1CCCN2C3=C([2H])C(Cl)=C([2H])C=C3SC4=CC([2H])=CC([2H])=C42. InChi Code: InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2/i2D,4D,6D,16D. InChi Key: RGCVKNLCSQQDEP-WNJORUDBSA-N.