Permethrin

Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide. It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or beta1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM. Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia. Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-alpha release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.Formal Name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester. CAS Number: 52645-53-1. Molecular Formula: C21H20Cl2O3. Formula Weight: 391.3. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 16 mg/ml, Ethanol: 14 mg/ml. SMILES: O=C(C1C(C)(C)C1/C=C(Cl)/Cl)OCC2=CC(OC3=CC=CC=C3)=CC=C2. InChi Code: InChI=1S/C21H20Cl2O3/c1-21(2)17(12-18(22)23)19(21)20(24)25-13-14-7-6-10-16(11-14)26-15-8-4-3-5-9-15/h3-12,17,19H,13H2,1-2H3. InChi Key: RLLPVAHGXHCWKJ-UHFFFAOYSA-N.