Periciazine

Periciazine is a typical antipsychotic. It binds to the dopamine D1 receptor and androgen receptor (Kis = 0.01 and 3 µM, respectively). Periciazine is an alpha1-adrenergic receptor (alpha1-AR) antagonist (IC50 = 0.0041 µM in rat forebrain homogenates), as well as an alpha2-AR antagonist (IC50 = 2 µM in rat cortical homogenates). It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) activity by 55% when used at a concentration of 100 µM. Periciazine (0.075 mg/kg) increases the number of entries into, and the percentage of time spent in, the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity. Formulations containing periciazine have been used in the treatment of schizophrenia and psychosis.Formal Name: 10-[3-(4-hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile. CAS Number: 2622-26-6. Synonyms: Propericiazine, RP 8909, SKF 20,716. Molecular Formula: C21H23N3OS. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, DMSO: 5 mg/ml, Methanol: Slightly soluble. lambdamax: 232, 273 nm. SMILES: N#CC1=CC=C2SC3=C(N(CCCN4CCC(CC4)O)C2=C1)C=CC=C3. InChi Code: InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2. InChi Key: LUALIOATIOESLM-UHFFFAOYSA-N.