Perhexiline (maleate)

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM). Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from beta-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.Formal Name: 2-(2,2-dicyclohexylethyl)-piperidine, 2Z-butenedioate. CAS Number: 6724-53-4. Molecular Formula: C19H35N . C4H4O4. Formula Weight: 393.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 210 nm. SMILES: OC(/C=C\C(O)=O)=O.C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1. InChi Code: InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18,5-3(6)1-2-4(7)8/h16-20H,1-15H2,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: JDZOTSLZMQDFLG-BTJKTKAUSA-N.