Pentostatin

Pentostatin is a purine antimetabolite and an adenosine deaminase (ADA) inhibitor (Ki = 0.09 nM). It reduces 2'-deoxyadenosine-induced growth inhibition of MOLT-4 lymphoblast cells (Ki = 5.6 µM). It inhibits erythrocyte and ascites tumor cell ADA in an L1210 murine skin lymphocytic leukemia model when administered at a dose of 0.2 mg/kg. Pentostatin (10 µg/animal) inhibits tumor growth and increases survival rate in a CT26/NY-ESO-1 mouse xenograft model. Formulations containing pentostatin have been used in the treatment of hairy cell leukemia.Formal Name: (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol. CAS Number: 53910-25-1. Synonyms: CI 825, CL 67310465, DCF, 2'-Deoxycoformycin, Deoxycoformycin, NSC 218321, NSC 247520. Molecular Formula: C11H16N4O4. Formula Weight: 268.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 286 nm. SMILES: OC[C@@H]1[C@@H](O)C[C@H](N2C=NC3=C2NC=NC[C@H]3O)O1. InChi Code: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1. InChi Key: FPVKHBSQESCIEP-JQCXWYLXSA-N.