Penciclovir

Penciclovir is a guanosine analog with antiviral activity. It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 µg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 µg/ml, respectively) and DNA synthesis (IC50 = 0.04 µg/ml) in MRC-5 cells., In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice. It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.Formal Name: 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one. CAS Number: 39809-25-1. Synonyms: BRL 39123. Molecular Formula: C10H15N5O3. Formula Weight: 253.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.33 mg/mL. lambdamax: 256 nm. SMILES: NC(NC1=C2N=CN1CCC(CO)CO)=NC2=O. InChi Code: InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18). InChi Key: JNTOCHDNEULJHD-UHFFFAOYSA-N.