Pellitorine

Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities. Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively). It inhibits production of TNF-alpha, IL-1alpha, and IL-1beta and phosphorylation of ERK1/2 induced by high mobility group protein B1 (HMGB1) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 20 µM. Pellitorine (9 µg/animal, i.v.) prolongs survival time in a mouse model of sepsis induced by HMGB1.Formal Name: (2E,4E)-N-(2-methylpropyl)-2,4-decadienamide. CAS Number: 18836-52-7. Molecular Formula: C14H25NO. Formula Weight: 223.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 259 nm. SMILES: O=C(/C=C/C=C/CCCCC)NCC(C)C. InChi Code: InChI=1S/C14H25NO/c1-4-5-6-7-8-9-10-11-14(16)15-12-13(2)3/h8-11,13H,4-7,12H2,1-3H3,(H,15,16)/b9-8+,11-10+. InChi Key: MAGQQZHFHJDIRE-BNFZFUHLSA-N. Origin: Plant/Piper longum.