PDIC-NS

PDIC-NS is an activator of stimulator of interferon genes (STING). It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial DNA (mtDNA), and increases levels of phosphorylated TANK-binding kinase 1 (Tbk1), interferon regulating factor 3 (Irf3), and STING in, as well as increases secretion of 2',3'-cGAMP and ATP from, LL/2 cells. It decreases tumor volume and weight and increases the percentage of intratumoral M1 macrophages and mature dendritic cells in an LL/2 mouse xenograft model when administered at a dose of 2 mg/kg twice per day. PDIC-NS (2.5 mg/kg twice per day) reduces lung weight and the number of lung metastases in wild-type and Sting1-/- mice in an LL/2 model of lung metastasis. It also increases serum levels of Ifn-beta, Ifn-gamma, Tnf-alpha, and chemokine (C-X-C motif) ligand 10 (Cxcl10), as well as increases the percentage of intratumoral CD4+, CD8+, and CD38+ T cells, in wild-type mice, and, to a lesser extent, in Sting1-/- mice, in the same model.Formal Name: 2,2'-(5,6,12,13-tetrachloro-1,3,8,10-tetraoxo-1,3,8,10-tetrahydroanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-2,9-diyl)bis(N,N-dimethylethan-1-aminium), dimethanesulfonate. Molecular Formula: C32H26Cl4N4O4 . 2CH3SO3. Formula Weight: 862.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: slightly soluble. SMILES: O=C1N(CC[NH+](C)C)C(C2=C(C1=CC(Cl)=C3C4=C(Cl)C=C(C(N(CC[NH+](C)C)C5=O)=O)C6=C5C=C(Cl)C7=C46)C3=C7C(Cl)=C2)=O.CS(=O)([O-])=O.CS(=O)([O-])=O. InChi Code: InChI=1S/C32H24Cl4N4O4.2CH4O3S/c1-37(2)5-7-39-29(41)13-9-17(33)23-25-19(35)11-15-22-16(32(44)40(31(15)43)8-6-38(3)4)12-20(36)26(28(22)25)24-18(34)10-14(30(39)42)21(13)27(23)24,2*1-5(2,3)4/h9-12H,5-8H2,1-4H3,2*1H3,(H,2,3,4). InChi Key: SFBAOLKOPZKFLZ-UHFFFAOYSA-N.