PDIC-NC

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent. It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM. PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively). It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.Formal Name: 5,6,12,13-tetrachloro-2,9-bis[2-(dimethylamino)ethyl]-anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone, dihydrochloride. CAS Number: 2633013-75-7. Molecular Formula: C32H24Cl4N4O4 . 2HCl. Formula Weight: 743.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C1N(CCN(C)C)C(C2=C(C1=CC(Cl)=C3C4=C(Cl)C=C(C(N(CCN(C)C)C5=O)=O)C6=C5C=C(Cl)C7=C46)C3=C7C(Cl)=C2)=O.Cl.Cl. InChi Code: InChI=1S/C32H24Cl4N4O4.2ClH/c1-37(2)5-7-39-29(41)13-9-17(33)23-25-19(35)11-15-22-16(32(44)40(31(15)43)8-6-38(3)4)12-20(36)26(28(22)25)24-18(34)10-14(30(39)42)21(13)27(23)24,,/h9-12H,5-8H2,1-4H3,2*1H. InChi Key: FFFBAHMNWCSWIN-UHFFFAOYSA-N.