PD 168568 (hydrochloride)

PD 168568 is a dopamine D4 receptor antagonist (Ki = 8.8 nM). It is selective for dopamine D4 over D2 receptors (Ki = 1,842 nM). PD 168568 (3 mg/kg) reverses amphetamine-induced hyperlocomotion in rats. It also inhibits the growth of glioblastoma neural stem cells when used at concentrations of 25 and 50 µM.Formal Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one, dihydrochloride. CAS Number: 1782532-06-2. Molecular Formula: C22H27N3O . 2HCl. Formula Weight: 422.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 50 mM. SMILES: O=C1NC(CCN2CCN(CC2)C3=CC(C)=C(C)C=C3)C4=CC=CC=C14.Cl.Cl. InChi Code: InChI=1S/C22H27N3O.2ClH/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21,,/h3-8,15,21H,9-14H2,1-2H3,(H,23,26),2*1H. InChi Key: RMNWLEGGYCVHFD-UHFFFAOYSA-N.