PD 153035

PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki = 5.2 pM, IC50 = 29 pM). It less effectively inhibits HER2 (IC50 = 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases. PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.Formal Name: N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine. CAS Number: 153436-54-5. Synonyms: AG-1517, NSC 669364, SU 5271. Molecular Formula: C16H14BrN3O2. Formula Weight: 360.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.3 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 222, 255, 346 nm. SMILES: COC(C(OC)=C1)=CC2=C1N=CN=C2NC3=CC(Br)=CC=C3. InChi Code: InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20). InChi Key: LSPANGZZENHZNJ-UHFFFAOYSA-N.