PD 150606

The calpains are a family of calcium-dependent cysteine proteases which catalyze limited proteolysis of substrates. PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 µM for µ-calpain (calpain-1) and 0.37 µM for m-calpain (calpain-2)). PD 150606 is commonly used to elucidate the roles for calpains in cell function, particularly in how they relate to apoptosis.Formal Name: 3-(4-iodophenyl)-2Z-mercapto-2-propenoic acid. CAS Number: 179528-45-1. Molecular Formula: C9H7IO2S. Formula Weight: 306.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 259, 320 nm. SMILES: IC1=CC=C(/C=C(S)/C(O)=O)C=C1. InChi Code: InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-. InChi Key: DJCVSFWGKYHMKH-YVMONPNESA-N.