(+)-PD 128907 (hydrochloride)

(+)-PD 128907 is a potent agonist of the dopamine 3 (D3) receptor (Ki = 1 nM). It shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM, respectively). Low doses of (+)-PD 128907 (13 µg/kg, s.c.) reduce spontaneous locomotor activity in rats. It blocks stereotypy induced by the NMDA receptor antagonist (+)-MK-801 (Cay-10009019) in mice. (+)-PD 128907 is used in animal models to study the role of the D3 receptor in nervous system disorders, such as schizophrenia, Parkinson's disease, and depression.Formal Name: 3,4,4aR,10bR-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol, monohydrochloride. CAS Number: 300576-59-4. Molecular Formula: C14H19NO3 . HCl. Formula Weight: 285.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: slightly, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 228, 297 nm. SMILES: OC1=CC=C(OC[C@]2([H])[C@]3([H])OCCN2CCC)C3=C1.Cl. InChi Code: InChI=1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15,/h3-4,8,12,14,16H,2,5-7,9H2,1H3,1H/t12-,14-,/m1./s1. InChi Key: DCFXOTRONMKUJB-QMDUSEKHSA-N.