PD-1/PD-L1 Inhibitor 1

PD-1/PD-L1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1). It inhibits the PD-1/PD-L1 interaction in a time-resolved FRET (TR-FRET) assay (IC50 = 6-100 nM). PD-1/PD-L1 inhibitor 1 reduces LPS-induced increases in PD-1 levels and apoptosis in MH-S mouse alveolar macrophages when used at a concentration of 1 µM. Surgical neointimal patching with PD-1/PD-L1-coated patches decreases neointimal thickness and inflammatory cell accumulation in a rat model of patch angioplasty.Formal Name: (2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid. CAS Number: 1675201-83-8. Synonyms: BMS-1, Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1. Molecular Formula: C29H33NO5. Formula Weight: 475.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 211, 236, 270 nm. SMILES: O=C(O)[C@@H]1CCCCN1CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC. InChi Code: InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1. InChi Key: ZBOYJODMIAUJHH-SANMLTNESA-N.