Palomid 529

Palomid 529 (P529) is an inhibitor of mammalian target of rapamycin complex (mTORC) formation. It is a derivative of a non-steroidal estrogen antagonist that has anti-angiogenic and anticancer activity but lacks estrogen receptor binding activity in estrogen binding assays in vitro. Palomid 529 inhibits VEGF-driven and bFGF-driven endothelial cell proliferation (IC50s = 20 and 30 nM, respectively) and reduces VEGF-A-driven phosphorylation of AktS473, an mTORC2 substrate. In vivo, palomid 529 inhibits retinal neovascularization in mice with oxygen-induced retinopathy, a commonly used assay for pathogenic angiogenesis, Ad-VEGF-A-driven angiogenesis, and phosphorylation of AktS473. Palomid 529 has anticancer effects in glioma cancer cells and xenografts via AktS473 signaling downtstream of mTORC.Formal Name: 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one. CAS Number: 914913-88-5. Synonyms: P529, RES-529, SG 00529. Molecular Formula: C24H22O6. Formula Weight: 406.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 25 mg/mL. lambdamax: 219, 279, 315 nm. SMILES: OC(C)C1=CC=C2C(C(OC3=C2C=C(OC)C(OCC4=CC=C(OC)C=C4)=C3)=O)=C1. InChi Code: InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3. InChi Key: YEAHTLOYHVWAKW-UHFFFAOYSA-N.