Pal-GHK

Pal-GHK is a form of the extracellular matrix-derived peptide GHK (Cay-27168) containing palmitic acid (Cay-10006627), which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK (0.5 µM) increases collagen synthesis in human skin fibroblasts in vitro. It reduces collagen degradation ex vivo in patient-derived human skin samples irradiated with UVA light when used at a concentration of 6 ppm. It has been used with the zwitterionic surfactant C12 dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS.Formal Name: N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine. CAS Number: 147732-56-7. Synonyms: C16-GHK, C16-GK-3, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-1. Molecular Formula: C30H54N6O5. Formula Weight: 578.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml. lambdamax: 283 nm. SMILES: O=C(N[C@H](C(O)=O)CCCCN)[C@@H](NC(CNC(CCCCCCCCCCCCCCC)=O)=O)CC1=CN=CN1. InChi Code: InChI=1S/C30H54N6O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27(37)33-22-28(38)35-26(20-24-21-32-23-34-24)29(39)36-25(30(40)41)17-15-16-19-31/h21,23,25-26H,2-20,22,31H2,1H3,(H,32,34)(H,33,37)(H,35,38)(H,36,39)(H,40,41)/t25-,26-/m0/s1. InChi Key: BYUQATUKPXLFLZ-UIOOFZCWSA-N.