P1075

P1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-Kir6) with an EC50 value of 45 nM for SUR2B-Kir6 channel activation. It is highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay). P1075 increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo. It also reduces infarct size in isolated rabbit hearts via activation of mitochondrial ATP-sensitive potassium channels (KATP, EC50s = 60-90 nM).Formal Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-guanidine. CAS Number: 60559-98-0. Molecular Formula: C12H17N5. Formula Weight: 231.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: <100mM, Ethanol: <50mM. lambdamax: 239 nm. SMILES: CCC(C)(C)/N=C(NC#N)/NC1=CC=CN=C1. InChi Code: InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17). InChi Key: HKZNADVVGXKQDL-UHFFFAOYSA-N.