p-nitro-Cyclic Pifithrin-alpha

Pifithrin-alpha (PFT-alpha, Cay-13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. Cyclic PFT-alpha (Cay-14748) is a stable analog of PFT-alpha. p-nitro-Cyclic PFT-alpha is a cell-permeable form of cyclic PFT-alpha. It is one order of magnitude more active that PFT-alpha in protecting cortical neurons exposed to etoposide (ED50 = 30 nM). p-nitro-Cyclic PFT-alpha acts in a p53-dependent manner but does not block phosphorylation of p53 on Ser15 in response to etoposide treatment, although it prevents p53 posttranscriptional activity. Although it is more stable in solution than the parent compound, this derivative is not active in vivo.Formal Name: 5,6,7,8-tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole. CAS Number: 60477-38-5. Synonyms: Cyclic pifithrin-alpha-p-nitro, p-nitro-Cyclic PFT-alpha. Molecular Formula: C15H13N3O2S. Formula Weight: 299.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml. lambdamax: 234, 349 nm. SMILES: O=[N+](C(C=C1)=CC=C1C2=CN(C(S3)=N2)C4=C3CCCC4)[O-]. InChi Code: InChI=1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2. InChi Key: XMFNSEDROOHGBY-UHFFFAOYSA-N.