Oxaliplatin

Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein crosslinks, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively). It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week. Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as an adjuvant in stage III colon cancer.Formal Name: (SP-4-2)-[1R,2R-cyclohexanediamine-kappaN1,kappaN2][ethanedioato(2-)-kappaO1,kappaO2]-platinum. CAS Number: 61825-94-3. Synonyms: Lipoxal, NSC 266046, RP 54780. Molecular Formula: C8H14N2O4Pt. Formula Weight: 397.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 0.01 mg/ml. SMILES: O=C1[O-][Pt+2]2([NH2]C(CCCC3)C3[NH2]2)[O-]C1=O. InChi Code: InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8,3-1(4)2(5)6,/h5-6H,1-4,7-8H2,(H,3,4)(H,5,6),/q,,+2/p-2. InChi Key: ZROHGHOFXNOHSO-UHFFFAOYSA-L.