OUL35

OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10, IC50 = 329 nM). It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 µM, respectively). OUL35 (10 µM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Cay-23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 µM.Formal Name: 4,4'-oxybis-benzamide. CAS Number: 6336-34-1. Synonyms: NSC 39047. Molecular Formula: C14H12N2O3. Formula Weight: 256.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 258 nm. SMILES: NC(C1=CC=C(OC2=CC=C(C(N)=O)C=C2)C=C1)=O. InChi Code: InChI=1S/C14H12N2O3/c15-13(17)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18). InChi Key: XZRCQWLPMXFGHE-UHFFFAOYSA-N.