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gamma-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism. Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease. OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 µM. It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.Formal Name: N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide. CAS Number: 519170-13-9. Molecular Formula: C16H15N3O3S2. Formula Weight: 361.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 203, 223, 274 nm. SMILES: COC1=CC=C(CC2=NN=C(NS(C3=CC=CC=C3)(=O)=O)S2)C=C1. InChi Code: InChI=1S/C16H15N3O3S2/c1-22-13-9-7-12(8-10-13)11-15-17-18-16(23-15)19-24(20,21)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,18,19). InChi Key: QCXWBMZVLJCKHF-UHFFFAOYSA-N.
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