Osthole

Osthole is a coumarin that has been found in C. monnieri and has diverse biological activities. It decreases secretion of hepatitis B surface antigen (HBsAg) from Huh7 cells transfected with hepatitis B virus (HBV) DNA by 70% when used at a concentration of 20 µg/ml. Osthole induces bone morphogenetic protein 2 (BMP2) production in and differentiation of MG-63 and hFOB osteoblast-like cells. It induces vasorelaxation in isolated rat blood vessels, ileum, corpus cavernosum, and trachea. Osthole inhibits migration and invasion of MCF-7, MDA-MB-231, H1299, and A549 cancer cells in vitro and increases survival in an SMMC-7721 hepatocellular carcinoma mouse xenograft model. It also has hepatoprotective effects in mouse models of hepatitis induced by concanavalin A (Cay-14951) and alcoholic fatty liver disease.Formal Name: 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one. CAS Number: 484-12-8. Synonyms: 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, NSC 31868. Molecular Formula: C15H16O3. Formula Weight: 244.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 257, 321 nm. SMILES: O=C1C=CC2=CC=C(OC)C(C/C=C(C)\C)=C2O1. InChi Code: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3. InChi Key: MBRLOUHOWLUMFF-UHFFFAOYSA-N. Origin: Plant/Cnidium monnieri.