Olsalazine (sodium salt)

Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA, Cay-70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA. In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM. Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4, Cay-20110) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Cay-23250). Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Cay-22586) when administered at a dose of 20 mg/kg. Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.Formal Name: 3,3'-(1,2-diazenediyl)bis[6-hydroxy-benzoic acid, disodium salt. CAS Number: 6054-98-4. Synonyms: C.I. 14130. Molecular Formula: C14H8N2O6 . 2Na. Formula Weight: 346.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 2 mg/ml. lambdamax: 219, 253, 362 nm. SMILES: [O-]C(C1=C(O)C=CC(/N=N/C2=CC=C(O)C(C([O-])=O)=C2)=C1)=O.[Na+].[Na+]. InChi Code: InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22,,/h1-6,17-18H,(H,19,20)(H,21,22),,/q,2*+1/p-2/b16-15+,,. InChi Key: ZJEFYLVGGFISGT-VRZXRVJBSA-L.