Olmesartan-d6

Olmesartan-d6 is intended for use as an internal standard for the quantification of olmesartan (Cay-23412) by GC- or LC-MS. Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Cay-11614). It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma. Olmesartan is selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II (Cay-17150, pD2 = 9.9) but not phenylephrine (Cay-17205, Cay-18619) or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.Formal Name: 4-[1-hydroxy-1-(methyl-d3)ethyl-2,2,2-d3]-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid. CAS Number: 1185144-74-4. Molecular Formula: C24H20D6N6O3. Formula Weight: 452.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C1=C(C(O)=O)N(CC(C=C2)=CC=C2C3=C(C4=NN=NN4)C=CC=C3)C(CCC)=N1. InChi Code: InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)/i2D3,3D3. InChi Key: VTRAEEWXHOVJFV-XERRXZQWSA-N.