Olaparib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM),... more
Product information "Olaparib"
Description: Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 µM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity. Target: PARP, Mitophagy, Autophagy. Smiles: C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3. References: Prasad CB, et al. Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property. Sci Rep. 2017 Oct 9,7(1):12876.
| Keywords: | KU0059436, AZD2281 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3015 |
Properties
| Application: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| MW: | 434.46 D |
| Formula: | C24H23FN4O3 |
Database Information
| CAS : | 763113-22-0| Matching products |
| KEGG ID : | K10798 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H360, H372 |
| P Phrases: | P201, P202, P260, P264, P270, P280, P314, P321, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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