O-Demethyl Apremilast

Item number	Size	Manual	Delivery time	Price
TGM-T35929-5mg	5 mg	-	7 - 10 business days*	151.00€
TGM-T35929-10mg	10 mg	-	7 - 10 business days*	281.00€
TGM-T35929-25mg	25 mg	-	7 - 10 business days*	661.00€

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Description: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4)... more

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Product information "O-Demethyl Apremilast"

Description: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 8.3 and 5.6 µM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3. Target: Others. Smiles: CCOc1cc(ccc1O)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O. References: Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral administrationXenobiotica41(12)1063-1075(2011)

Supplier:	TargetMol
Supplier-Nr:	T35929

Properties

Application:	Apremilast active metabolite, PDE4 inhibitor
MW:	446.47 D
Formula:	C21H22N2O7S

Database Information

CAS :	1384441-38-6\| Matching products
KEGG ID :	K13293 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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