O-Demethyl Apremilast

O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast (Cay-18502). It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs, IC50s = 8.3 and 5.6 µM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.Formal Name: N-[2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-acetamide. CAS Number: 1384441-38-6. Synonyms: 4'-hydroxy APR. Molecular Formula: C21H22N2O7S. Formula Weight: 446.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 231 nm. SMILES: CS(C[C@H](C1=CC(OCC)=C(C=C1)O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)(=O)=O. InChi Code: InChI=1S/C21H22N2O7S/c1-4-30-18-10-13(8-9-17(18)25)16(11-31(3,28)29)23-20(26)14-6-5-7-15(22-12(2)24)19(14)21(23)27/h5-10,16,25H,4,11H2,1-3H3,(H,22,24)/t16-/m1/s1. InChi Key: PEUJABWEZWJNBO-MRXNPFEDSA-N.