NVS-STG2

NVS-STG2 is an agonist of stimulator of interferon genes (STING). It binds to STING and induces STING activation in a reporter assay (IC50 = 5.2 µM). Intratumoral injection of NVS-STG2 (400 or 800 µg/animal) reduces tumor volume and increases intratumoral IFN-gamma levels in a B16.SIY murine melanoma model.Formal Name: 4-((4-(2-(tert-butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid. Molecular Formula: C25H33NO5. Formula Weight: 427.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml. SMILES: OC(C1=CC=C(NCC2=CC=C(C3(C(C)(C)C)OCC(C)(C)CO3)C=C2)C(OC)=C1)=O. InChi Code: InChI=1S/C25H33NO5/c1-23(2,3)25(30-15-24(4,5)16-31-25)19-10-7-17(8-11-19)14-26-20-12-9-18(22(27)28)13-21(20)29-6/h7-13,26H,14-16H2,1-6H3,(H,27,28). InChi Key: CZSPKEVHLRWAFC-UHFFFAOYSA-N.