NVP-ACC789

NVP-ACC789 is an inhibitor of VEGF receptor tyrosine kinases (VEGFRs, IC50s = 0.38, 0.02, 0.18, and 0.23 µM for human VEGFR1, 2, 3, and mouse Vegfr2, respectively). It is selective for VEGFRs over FGFRs and PDGFRalpha (IC50s = >10 µM) but has activity at PDGFRbeta (IC50 = 1.4 µM) in an enzyme assay. NVP-ACC789 inhibits VEGF-induced VEGFR2 autophosphorylation (IC50 = 11.5 nM in CHO cells transfected with the human receptor). It also inhibits VEGF- and bFGF-induced angiogenesis and cell migration of BAE and BME cells. In vivo, NVP-ACC789 blocks bFGF- and VEGF-induced angiogenesis (ED50s = 9 and 26 mg/kg, respectively) in a mouse model of growth factor-induced angiogenesis.Formal Name: N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine. CAS Number: 300842-64-2. Molecular Formula: C21H17BrN4. Formula Weight: 405.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMF:PBS (pH 7) (1:10): 0.09 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 215, 337 nm. SMILES: BrC1=CC(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42)=CC=C1C. InChi Code: InChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26). InChi Key: GXWKSXUPEFVUOO-UHFFFAOYSA-N.