NSC 624206

NSC 624206 is an inhibitor of ubiquitin-activating enzyme (E1) that specifically blocks ubiquitin-thioester formation (IC50 = 13 µM) but has no effect on ubiquitin adenylation. Through this action, NSC 624206 prevents the ubiquitination and degradation of the tumor suppressor protein p27 in vitro.Formal Name: N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-1-decanamine, monohydrochloride. CAS Number: 13116-77-3. Molecular Formula: C19H32ClNS2 . HCl. Formula Weight: 410.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.16 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 225 nm. SMILES: ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl. InChi Code: InChI=1S/C19H32ClNS2.ClH/c1-2-3-4-5-6-7-8-9-14-21-15-16-22-23-17-18-10-12-19(20)13-11-18,/h10-13,21H,2-9,14-17H2,1H3,1H. InChi Key: JQHUAYXPNPTQRO-UHFFFAOYSA-N.