NSC 23005 (sodium salt)

NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen. It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term HSCs following treatment with a CDK2 inhibitor but not a CDK4/6 inhibitor, indicating that it mediates its effects by blocking p18 inhibition of CDK4/6. It increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation.Formal Name: 4-[(cyclohexylamino)sulfonyl]-benzoic acid, monosodium salt. CAS Number: 1796596-46-7. Molecular Formula: C13H16NO4S . Na. Formula Weight: 305.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.2 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 202, 239 nm. SMILES: O=S(NC1CCCCC1)(C2=CC=C(C([O-])=O)C=C2)=O.[Na+]. InChi Code: InChI=1S/C13H17NO4S.Na/c15-13(16)10-6-8-12(9-7-10)19(17,18)14-11-4-2-1-3-5-11,/h6-9,11,14H,1-5H2,(H,15,16),/q,+1/p-1. InChi Key: MLHFBDVMTRIQMW-UHFFFAOYSA-M.