NSC 109555

Description: NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 µM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 µM). Inhibits histone H1 phosphorylation (IC50 = 0.24 µM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo. Target: Others. Smiles: CS(O)(=O)=O.CS(O)(=O)=O.C\C(=N/N=C(N)N)c1ccc(NC(=O)Nc2ccc(cc2)C(\C)=N\N=C(N)N)cc1. References: Duong HQ, et al. Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine. J Cell Mol Med. 2013 Oct,17(10):1261-70.