NS 638

NS 638 is an inhibitor of the N-type voltage-gated calcium channel Cav2.2 and CNS L-type calcium channels. It inhibits potassium-induced calcium uptake in chick cortical synaptosomes (IC50 = 3.4 µM) and AMPA-induced GABA release from primary chick cortical neurons (IC50 = 4.3 µM), effects that can be blocked by the N-type calcium channel inhibitor omega-conotoxin GVIA (Cay-24114) but not the L-type calcium channel inhibitor nifedipine (Cay-11106). It also inhibits potassium-induced calcium level increases in primary chick cerebellar granule cells (IC50 = 3.4 µM), an effect that can be blocked by nifedipine but not omega-conotoxin GVIA. NS 638 (50 mg/kg) reduces infarct volume in a mouse model of focal ischemia induced by middle cerebral artery occlusion (MCAO) but not in a gerbil model of global ischemia induced by bilateral carotid artery occlusion (BCAO).Formal Name: 1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-1H-benzimidazol-2-amine. CAS Number: 150493-34-8. Molecular Formula: C15H11ClF3N3. Formula Weight: 325.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. SMILES: FC(F)(C1=CC(N=C(N2CC3=CC=C(C=C3)Cl)N)=C2C=C1)F. InChi Code: InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21). InChi Key: GXQCVUZORDAARJ-UHFFFAOYSA-N.